Acute studies are short term exposure studies.
It includes the other factors such as sex,
species, strain, age, diet, nutritional status,
general health conditions, animal husbandry,
experimental procedure, route of administration,
stress, dosage and formulation etc.
Acute studies are conducted for the purpose of determining LD50 of a test substance.
But LD50 is not absolute biological constant to be equated.
LD50 : It is
the killing power of highly toxic substance
and obtain safe dose from lethal.
The adverse effects occurring in a short time
of administration of a single dose/ multiple
doses given within 24 hours.
of Acute Testing :