Our Services  

  • Mutagenicity (Genetic Toxicology)

Genetic toxicology is sub specialty of toxicology which identifies and analyses the toxicity directed towards the hereditary components of living organisms. These tests detects and access the genetic hazard from agents that are highly specific for nucleic acids and are capable of damaging the genetic material at sub toxic concentrations. These agents are termed as ‘Genotoxic’. The battery of the test system includes–

  • Ames Salmonella / Microsome Mutagenicity Test
    It is a simple and rapid test used to identify chemical carcinogens and mutagens. The test detects these chemicals by means of their mutagenicity and it is about 90% accurate in detecting carcinogens as mutagens. Special strains of Salmonella typhimurium are used for measuring DNA damage and these are combined with liver homogenates from rodents.

  • In vivo Micronucleus Test in Mice (MNT)
    MNT is being increasingly used in this field of chemical mutagenesis. The test serves as a useful indicator of cytogenetic damage and has to date proved to be convenient and rapid method of screening chromosomal damage in vivo in mice.

  • In vivo Chromosomal Aberration Test (CA)
    Chromosomal aberrations are due to lesion in DNA which lead to discontinuities of the DNA double helix. Double strand breaks lead to immediate fixation of the aberrations by misrepair. Depending on the time induction within the cell cycle, the types of aberrations observed at the succeeding metaphase.

  • In vitro chromosomal aberration test in human lymphocytes
    The studies of CA in cultured lymphocytes offer a good method for dose estimation in persons exposed to chemicals and proved to be useful in screening of potentially mutagenic and carcinogenic agents.

  • Dominant lethal test in mice
    Dominant lethal mutation is a genetic event that kills the individual which carries it in a heterozygous state. Dominant lethal mutations are produced mainly due to induction of structural and numerical chromosomal abnormalities induced in the paternal germ cell.
    
© TOXINDIA. Best viewed in 1024 X 768. Developed by  Softkey Solutions